Screening of suitable solvents in organic synthesis. Strategies for solvent selection
- Authors
- Rolf Carlson, Torbjörn Lundstedt and Christer Albano
- Published
- 1985
- DOI
- 10.3891/acta.chem.scand.39b-0079
- Citation
- Carlson et al.: "Screening of suitable solvents in organic synthesis. Strategies for solvent selection", Acta Chemica Scandinavica, B39, 79-91, 1985.
- Abstract
- The problem of selecting test solvents for the study of new organic synthetic methods is discussed. Eight common descriptors of solvent properties for 82 different solvents were analyzed by principal components (PC) analysis. On the basis of the systematic variation of the descriptors, as revealed by the PC-analysis, different strategies for a systematic selection of test solvents are discussed. Among these strategies are selection by a sequential simplex procedure and selection by D-optimal designs.
- Tags
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